PDX:PBX complexes are required for normal proliferation of pancreatic cells during development

The homeobox factor PDX-1 is a key regulator of pancreatic morphogenesis and glucose homeostasis; targeted disruption of the PDX-1 gene leads to pancreatic agenesis in pdx-1(−/−) homozygotes. Pdx-1 heterozygotes develop normally, but they display glucose intolerance in adulthood. Like certain other...

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Detalhes bibliográficos
Main Authors: Dutta, Sanjoy, Gannon, Maureen, Peers, Bernard, Wright, Chris, Bonner-Weir, Susan, Montminy, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC14709/
https://ncbi.nlm.nih.gov/pubmed/11158595
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