Threshold-dependent cooperativity of Pdx1 and Oc1 in pancreatic progenitors establishes competency for endocrine differentiation and β-cell function

Pdx1 and Oc1 are co-expressed in multipotent pancreatic progenitors and regulate the pro-endocrine gene Neurog3. Their expression diverges in later organogenesis, with Oc1 absent from hormone+ cells and Pdx1 maintained in mature β cells. In a classical genetic test for cooperative functional interac...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Henley, Kathryn D., Stanescu, Diana E., Kropp, Peter A., Wright, Christopher V.E., Won, Kyoung-Jae, Stoffers, Doris A., Gannon, Maureen
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4917419/
https://ncbi.nlm.nih.gov/pubmed/27292642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.05.040
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