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PDX:PBX complexes are required for normal proliferation of pancreatic cells during development

The homeobox factor PDX-1 is a key regulator of pancreatic morphogenesis and glucose homeostasis; targeted disruption of the PDX-1 gene leads to pancreatic agenesis in pdx-1(−/−) homozygotes. Pdx-1 heterozygotes develop normally, but they display glucose intolerance in adulthood. Like certain other...

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書誌詳細
主要な著者: Dutta, Sanjoy, Gannon, Maureen, Peers, Bernard, Wright, Chris, Bonner-Weir, Susan, Montminy, Marc
フォーマット: Artigo
言語:Inglês
出版事項: The National Academy of Sciences 2001
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC14709/
https://ncbi.nlm.nih.gov/pubmed/11158595
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