Neutrophil-independent mechanisms of caspase-1– and IL-18–mediated ischemic acute tubular necrosis in mice

Having recently described the injurious role of caspase-1–mediated production of the proinflammatory cytokine IL-18 in ischemic acute renal failure (ARF), we report here on the effect of the newly developed caspase inhibitor Quinoline-Val-Asp(Ome)-CH(2)-OPH (OPH-001) on caspase-1, IL-18, neutrophil...

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Autores principales: Melnikov, Vyacheslav Y., Faubel, Sarah, Siegmund, Britta, Lucia, M. Scott, Ljubanovic, Danica, Edelstein, Charles L.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2002
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC150794/
https://ncbi.nlm.nih.gov/pubmed/12393844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI15623
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