Gads/Grb2-Mediated Association with LAT Is Critical for the Inhibitory Function of Gab2 in T Cells

A docking protein, Gab2, is recruited to the vicinity of the TCR complex and inhibits downstream signaling by interaction with negative regulators. However, the molecular mechanisms of this recruitment remain unclear. We have found that Gab2 associates with LAT upon TCR stimulation and that LAT is e...

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Detalhes bibliográficos
Main Authors: Yamasaki, Sho, Nishida, Keigo, Sakuma, Machie, Berry, Donna, McGlade, C. Jane, Hirano, Toshio, Saito, Takashi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC150736/
https://ncbi.nlm.nih.gov/pubmed/12640133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.7.2515-2529.2003
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