Gads/Grb2-Mediated Association with LAT Is Critical for the Inhibitory Function of Gab2 in T Cells

A docking protein, Gab2, is recruited to the vicinity of the TCR complex and inhibits downstream signaling by interaction with negative regulators. However, the molecular mechanisms of this recruitment remain unclear. We have found that Gab2 associates with LAT upon TCR stimulation and that LAT is e...

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Detalles Bibliográficos

Publicado en:	Mol Cell Biol
Autores principales:	Yamasaki, Sho, Nishida, Keigo, Sakuma, Machie, Berry, Donna, McGlade, C. Jane, Hirano, Toshio, Saito, Takashi
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Taylor & Francis 2003
Materias:	Cell Growth and Development
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC150736/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12640133/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.7.2515-2529.2003
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