Gads/Grb2-Mediated Association with LAT Is Critical for the Inhibitory Function of Gab2 in T Cells

A docking protein, Gab2, is recruited to the vicinity of the TCR complex and inhibits downstream signaling by interaction with negative regulators. However, the molecular mechanisms of this recruitment remain unclear. We have found that Gab2 associates with LAT upon TCR stimulation and that LAT is e...

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Bibliografiska uppgifter
Huvudupphovsmän: Yamasaki, Sho, Nishida, Keigo, Sakuma, Machie, Berry, Donna, McGlade, C. Jane, Hirano, Toshio, Saito, Takashi
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2003
Ämnen:
Cell Growth and Development
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC150736/
https://ncbi.nlm.nih.gov/pubmed/12640133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.7.2515-2529.2003
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