Gads/Grb2-Mediated Association with LAT Is Critical for the Inhibitory Function of Gab2 in T Cells

A docking protein, Gab2, is recruited to the vicinity of the TCR complex and inhibits downstream signaling by interaction with negative regulators. However, the molecular mechanisms of this recruitment remain unclear. We have found that Gab2 associates with LAT upon TCR stimulation and that LAT is e...

Full description

Saved in:
Bibliographic Details
Main Authors: Yamasaki, Sho, Nishida, Keigo, Sakuma, Machie, Berry, Donna, McGlade, C. Jane, Hirano, Toshio, Saito, Takashi
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2003
Subjects:
Cell Growth and Development
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC150736/
https://ncbi.nlm.nih.gov/pubmed/12640133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.7.2515-2529.2003
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items