The multi-site docking protein Grb2-associated binder 1 (Gab1) enhances interleukin-6-induced MAPK-pathway activation in an SHP2-, Grb2-, and time-dependent manner

Abstract Background Cytokine-dependent activation of signalling pathways is tightly orchestrated. The spatiotemporal activation of signalling pathways dictates the specific physiological responses to cytokines. Dysregulated signalling accounts for neoplastic, developmental, and inflammatory diseases...

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Autors principals:	Hannes Bongartz, Karen Gille, Wiebke Hessenkemper, Katharina Mandel, Marc Lewitzky, Stephan M. Feller, Fred Schaper
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2019-10-01
Col·lecció:	Cell Communication and Signaling
Matèries:	Interleukin-6 IL-6 Janus kinase Jak Gab1 SHP2
Accés en línia:	http://link.springer.com/article/10.1186/s12964-019-0451-2
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