DNA Hypermethylation in Drosophila melanogaster Causes Irregular Chromosome Condensation and Dysregulation of Epigenetic Histone Modifications

The level of genomic DNA methylation plays an important role in development and disease. In order to establish an experimental system for the functional analysis of genome-wide hypermethylation, we overexpressed the mouse de novo methyltransferase Dnmt3a in Drosophila melanogaster. These flies showe...

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Autori principali: Weissmann, Frank, Muyrers-Chen, Inhua, Musch, Tanja, Stach, Dirk, Wiessler, Manfred, Paro, Renato, Lyko, Frank
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2003
Soggetti:
DNA Dynamics and Chromosome Structure
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC150732/
https://ncbi.nlm.nih.gov/pubmed/12640138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.7.2577-2586.2003
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