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DNA Hypermethylation in Drosophila melanogaster Causes Irregular Chromosome Condensation and Dysregulation of Epigenetic Histone Modifications

The level of genomic DNA methylation plays an important role in development and disease. In order to establish an experimental system for the functional analysis of genome-wide hypermethylation, we overexpressed the mouse de novo methyltransferase Dnmt3a in Drosophila melanogaster. These flies showe...

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Bibliografski detalji
Glavni autori: Weissmann, Frank, Muyrers-Chen, Inhua, Musch, Tanja, Stach, Dirk, Wiessler, Manfred, Paro, Renato, Lyko, Frank
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2003
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC150732/
https://ncbi.nlm.nih.gov/pubmed/12640138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.7.2577-2586.2003
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