DNA Hypermethylation in Drosophila melanogaster Causes Irregular Chromosome Condensation and Dysregulation of Epigenetic Histone Modifications

The level of genomic DNA methylation plays an important role in development and disease. In order to establish an experimental system for the functional analysis of genome-wide hypermethylation, we overexpressed the mouse de novo methyltransferase Dnmt3a in Drosophila melanogaster. These flies showe...

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Detalhes bibliográficos
Main Authors: Weissmann, Frank, Muyrers-Chen, Inhua, Musch, Tanja, Stach, Dirk, Wiessler, Manfred, Paro, Renato, Lyko, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
DNA Dynamics and Chromosome Structure
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC150732/
https://ncbi.nlm.nih.gov/pubmed/12640138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.7.2577-2586.2003
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