MEK Kinase 2 and the Adaptor Protein Lad Regulate Extracellular Signal-Regulated Kinase 5 Activation by Epidermal Growth Factor via Src

Lad is an SH2 domain-containing adaptor protein that binds MEK kinase 2 (MEKK2), a mitogen-activated protein kinase (MAPK) kinase kinase for the extracellular signal-regulated kinase 5 (ERK5) and JNK pathways. Lad and MEKK2 are in a complex in resting cells. Antisense knockdown of Lad expression and...

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Autors principals: Sun, Weiyong, Wei, Xudong, Kesavan, Kamala, Garrington, Timothy P., Fan, Ruihua, Mei, Junjie, Anderson, Steven M., Gelfand, Erwin W., Johnson, Gary L.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2003
Matèries:
Cell Growth and Development
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC150715/
https://ncbi.nlm.nih.gov/pubmed/12640115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.7.2298-2308.2003
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