Melanosomal sequestration of cytotoxic drugs contributes to the intractability of malignant melanomas

Multidrug resistance mechanisms underlying the intractability of malignant melanomas remain largely unknown. In this study, we demonstrate that the development of multidrug resistance in melanomas involves subcellular sequestration of intracellular cytotoxic drugs such as cis-diaminedichloroplatinum...

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Autori principali: Chen, Kevin G., Valencia, Julio C., Lai, Barry, Zhang, Guofeng, Paterson, Jill K., Rouzaud, François, Berens, Werner, Wincovitch, Stephen M., Garfield, Susan H., Leapman, Richard D., Hearing, Vincent J., Gottesman, Michael M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2006
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1502551/
https://ncbi.nlm.nih.gov/pubmed/16777967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0600213103
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