Melanosomal sequestration of cytotoxic drugs contributes to the intractability of malignant melanomas

Multidrug resistance mechanisms underlying the intractability of malignant melanomas remain largely unknown. In this study, we demonstrate that the development of multidrug resistance in melanomas involves subcellular sequestration of intracellular cytotoxic drugs such as cis-diaminedichloroplatinum...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Chen, Kevin G., Valencia, Julio C., Lai, Barry, Zhang, Guofeng, Paterson, Jill K., Rouzaud, François, Berens, Werner, Wincovitch, Stephen M., Garfield, Susan H., Leapman, Richard D., Hearing, Vincent J., Gottesman, Michael M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2006
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC1502551/
https://ncbi.nlm.nih.gov/pubmed/16777967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0600213103
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