Melanosomal sequestration of cytotoxic drugs contributes to the intractability of malignant melanomas

Multidrug resistance mechanisms underlying the intractability of malignant melanomas remain largely unknown. In this study, we demonstrate that the development of multidrug resistance in melanomas involves subcellular sequestration of intracellular cytotoxic drugs such as cis-diaminedichloroplatinum...

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Detalhes bibliográficos
Main Authors: Chen, Kevin G., Valencia, Julio C., Lai, Barry, Zhang, Guofeng, Paterson, Jill K., Rouzaud, François, Berens, Werner, Wincovitch, Stephen M., Garfield, Susan H., Leapman, Richard D., Hearing, Vincent J., Gottesman, Michael M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1502551/
https://ncbi.nlm.nih.gov/pubmed/16777967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0600213103
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