Influence of Melanosome Dynamics on Melanoma Drug Sensitivity

BACKGROUND: Malignant melanomas are intrinsically resistant to many conventional treatments, such as radiation and chemotherapy, for reasons that are poorly understood. Here we propose and test a model that explains drug resistance or sensitivity in terms of melanosome dynamics. METHODS: The growth...

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Autors principals: Chen, Kevin G., Leapman, Richard D., Zhang, Guofeng, Lai, Barry, Valencia, Julio C., Cardarelli, Carol O., Vieira, Wilfred D., Hearing, Vincent J., Gottesman, Michael M.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2009
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2744727/
https://ncbi.nlm.nih.gov/pubmed/19704071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djp259
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