gp130 signaling in proopiomelanocortin neurons mediates the acute anorectic response to centrally applied ciliary neurotrophic factor

Ciliary neurotrophic factor (CNTF) exerts anorectic effects by overcoming leptin resistance via activation of hypothalamic neurons. However, the exact site of CNTF action in the hypothalamus has not yet been identified. Using Cre-loxP-mediated recombination in vivo, we have selectively ablated the c...

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Autores principales: Janoschek, Ruth, Plum, Leona, Koch, Linda, Münzberg, Heike, Diano, Sabrina, Shanabrough, Marya, Müller, Werner, Horvath, Tamas L., Brüning, Jens C.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2006
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1502296/
https://ncbi.nlm.nih.gov/pubmed/16818888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0600425103
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