Biosynthesis of tumorigenic HER2 C-terminal fragments by alternative initiation of translation

The overactivation of the HERs, a family of tyrosine kinase receptors, leads to the development of cancer. Although the canonical view contemplates HER receptors restricted to the secretory and endocytic pathways, full-length HER1, HER2 and HER3 have been detected in the nucleoplasm. Furthermore, li...

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Main Authors: Anido, Judit, Scaltriti, Maurizio, Bech Serra, Joan Josep, Josefat, Belén Santiago, Rojo Todo, Federico, Baselga, José, Arribas, Joaquín
Format: Artigo
Sprog:Inglês
Udgivet: 2006
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1500971/
https://ncbi.nlm.nih.gov/pubmed/16794579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601191
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