A Naturally Occurring HER2 Carboxy-Terminal Fragment Promotes Mammary Tumor Growth and Metastasis

HER2 is a tyrosine kinase receptor causally involved in cancer. A subgroup of breast cancer patients with particularly poor clinical outcomes expresses a heterogeneous collection of HER2 carboxy-terminal fragments (CTFs). However, since the CTFs lack the extracellular domain that drives dimerization...

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Hauptverfasser: Pedersen, Kim, Angelini, Pier-Davide, Laos, Sirle, Bach-Faig, Alba, Cunningham, Matthew P., Ferrer-Ramón, Cristina, Luque-García, Antonio, García-Castillo, Jesús, Parra-Palau, Josep Lluis, Scaltriti, Maurizio, y Cajal, Santiago Ramón, Baselga, José, Arribas, Joaquín
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2009
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2698729/
https://ncbi.nlm.nih.gov/pubmed/19364815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01803-08
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