Two conformations of a crystalline human tRNA synthetase–tRNA complex: implications for protein synthesis

Aminoacylation of tRNA is the first step of protein synthesis. Here, we report the co-crystal structure of human tryptophanyl-tRNA synthetase and tRNA(Trp). This enzyme is reported to interact directly with elongation factor 1α, which carries charged tRNA to the ribosome. Crystals were generated fro...

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Main Authors: Yang, Xiang-Lei, Otero, Francella J, Ewalt, Karla L, Liu, Jianming, Swairjo, Manal A, Köhrer, Caroline, RajBhandary, Uttam L, Skene, Robert J, McRee, Duncan E, Schimmel, Paul
Format: Artigo
Language:Inglês
Published: 2006
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1500858/
https://ncbi.nlm.nih.gov/pubmed/16724112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601154
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