The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity

The eukaryotic translation initiation factor 4B (eIF4B) plays a critical role in recruiting the 40S ribosomal subunit to the mRNA. In response to insulin, eIF4B is phosphorylated on Ser422 by S6K in a rapamycin-sensitive manner. Here we demonstrate that the p90 ribosomal protein S6 kinase (RSK) phos...

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Bibliografiset tiedot
Päätekijät: Shahbazian, David, Roux, Philippe P, Mieulet, Virginie, Cohen, Michael S, Raught, Brian, Taunton, Jack, Hershey, John W B, Blenis, John, Pende, Mario, Sonenberg, Nahum
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2006
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC1500846/
https://ncbi.nlm.nih.gov/pubmed/16763566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601166
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