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The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity
The eukaryotic translation initiation factor 4B (eIF4B) plays a critical role in recruiting the 40S ribosomal subunit to the mRNA. In response to insulin, eIF4B is phosphorylated on Ser422 by S6K in a rapamycin-sensitive manner. Here we demonstrate that the p90 ribosomal protein S6 kinase (RSK) phos...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1500846/ https://ncbi.nlm.nih.gov/pubmed/16763566 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601166 |
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