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Structure and allosteric regulation of the αXβ2 integrin I domain

The integrin αXβ2 (CD11c/CD18, p150,95) binds ligands through the I domain of the αX subunit. Ligands include the complement factor fragment iC3b, a key component in the innate immune defense, which, together with the expression of αXβ2 on dendritic cells and on other leukocytes, suggests a role in...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Vorup-Jensen, Thomas, Ostermeier, Christian, Shimaoka, Motomu, Hommel, Ulrich, Springer, Timothy A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2003
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC149926/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12554829/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0237387100
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