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Flexible lid to the p53-binding domain of human Mdm2: Implications for p53 regulation
The stabilization of p53 against Mdm2-mediated degradation is an important event in DNA damage response. Initial models of p53 stabilization focused on posttranslational modification of p53 that would disrupt the p53–Mdm2 interaction. The N-terminal regions of both p53 and Mdm2 are modified in vivo...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The National Academy of Sciences
2003
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC149886/ https://ncbi.nlm.nih.gov/pubmed/12552135 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0334477100 |
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