Histone deacetylation by Sir2 generates a transcriptionally repressed nucleoprotein complex

Sir2 is an NAD-dependent histone deacetylase required for transcriptional silencing. To study the mechanism of Sir2 function, we examined the biochemical properties of purified recombinant Drosophila Sir2 (dSir2). First, we performed histone deacetylation assays and found that dSir2 deacetylates a b...

ver descrição completa

Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Parsons, Xuejun Huang, Garcia, Sandra N., Pillus, Lorraine, Kadonaga, James T.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2003
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC149880/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12571358/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0434064100
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!