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Histone deacetylation by Sir2 generates a transcriptionally repressed nucleoprotein complex

Sir2 is an NAD-dependent histone deacetylase required for transcriptional silencing. To study the mechanism of Sir2 function, we examined the biochemical properties of purified recombinant Drosophila Sir2 (dSir2). First, we performed histone deacetylation assays and found that dSir2 deacetylates a b...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Parsons, Xuejun Huang, Garcia, Sandra N., Pillus, Lorraine, Kadonaga, James T.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2003
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC149880/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12571358/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0434064100
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