Histone deacetylation by Sir2 generates a transcriptionally repressed nucleoprotein complex

Sir2 is an NAD-dependent histone deacetylase required for transcriptional silencing. To study the mechanism of Sir2 function, we examined the biochemical properties of purified recombinant Drosophila Sir2 (dSir2). First, we performed histone deacetylation assays and found that dSir2 deacetylates a b...

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Библиографические подробности

Опубликовано в::	Proc Natl Acad Sci U S A
Главные авторы:	Parsons, Xuejun Huang, Garcia, Sandra N., Pillus, Lorraine, Kadonaga, James T.
Формат:	Artigo
Язык:	Inglês
Опубликовано:	National Academy of Sciences 2003
Предметы:	Biological Sciences
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC149880/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12571358/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0434064100
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