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Histone deacetylation by Sir2 generates a transcriptionally repressed nucleoprotein complex
Sir2 is an NAD-dependent histone deacetylase required for transcriptional silencing. To study the mechanism of Sir2 function, we examined the biochemical properties of purified recombinant Drosophila Sir2 (dSir2). First, we performed histone deacetylation assays and found that dSir2 deacetylates a b...
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| Huvudupphovsmän: | , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
The National Academy of Sciences
2003
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC149880/ https://ncbi.nlm.nih.gov/pubmed/12571358 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0434064100 |
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