Histone deacetylation by Sir2 generates a transcriptionally repressed nucleoprotein complex

Sir2 is an NAD-dependent histone deacetylase required for transcriptional silencing. To study the mechanism of Sir2 function, we examined the biochemical properties of purified recombinant Drosophila Sir2 (dSir2). First, we performed histone deacetylation assays and found that dSir2 deacetylates a b...

Disgrifiad llawn

Manylion Llyfryddiaeth

Cyhoeddwyd yn:	Proc Natl Acad Sci U S A
Prif Awduron:	Parsons, Xuejun Huang, Garcia, Sandra N., Pillus, Lorraine, Kadonaga, James T.
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	National Academy of Sciences 2003
Pynciau:	Biological Sciences
Mynediad Ar-lein:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC149880/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12571358/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0434064100
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!