Designed FHIT alleles establish that Fhit-induced apoptosis in cancer cells is limited by substrate binding

The FHIT gene is inactivated early in the development of many human tumors, and Fhit-deficient mice have increased cancer incidence. Viral reexpression of Fhit kills Fhit-deficient cells by induction of apoptosis. Fhit, a member of branch 2 of the histidine-triad superfamily of nucleoside monophosph...

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Bibliografiske detaljer
Main Authors: Trapasso, Francesco, Krakowiak, Agnieszka, Cesari, Rossano, Arkles, Jeffrey, Yendamuri, Sai, Ishii, Hideshi, Vecchione, Andrea, Kuroki, Tamotsu, Bieganowski, Pawel, Pace, Helen C., Huebner, Kay, Croce, Carlo M., Brenner, Charles
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2003
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC149877/
https://ncbi.nlm.nih.gov/pubmed/12574506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0437915100
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