The crystal structure of the complex between a disaccharide anthracycline and the DNA hexamer d(CGATCG) reveals two different binding sites involving two DNA duplexes

The crystal structure of the complex formed between the anthracycline antibiotic 3′-deamino-3′- hydroxy-4′-(O-l-daunosaminyl)-4-demethoxydoxo rubicin (MEN 10755), an active disaccharide analogue of doxorubicin, and the DNA hexamer d(CGATCG) has been solved to a resolution of 2.1 Å. MEN 10755 exhibit...

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Cyhoeddwyd yn:	Nucleic Acids Res
Prif Awduron:	Temperini, Claudia, Messori, Luigi, Orioli, Pierluigi, Bugno, Cristina Di, Animati, Fabio, Ughetto, Giovanni
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Oxford University Press 2003
Pynciau:	Articles
Mynediad Ar-lein:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC149838/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12595554/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkg245
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