The crystal structure of the complex between a disaccharide anthracycline and the DNA hexamer d(CGATCG) reveals two different binding sites involving two DNA duplexes
The crystal structure of the complex formed between the anthracycline antibiotic 3′-deamino-3′- hydroxy-4′-(O-l-daunosaminyl)-4-demethoxydoxo rubicin (MEN 10755), an active disaccharide analogue of doxorubicin, and the DNA hexamer d(CGATCG) has been solved to a resolution of 2.1 Å. MEN 10755 exhibit...
שמור ב:
| הוצא לאור ב: | Nucleic Acids Res |
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| Principais autores: | , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Oxford University Press
2003
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC149838/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12595554/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkg245 |
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