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Tetrameric Oligomerization of IκB Kinase γ (IKKγ) Is Obligatory for IKK Complex Activity and NF-κB Activation

The IκB kinase (IKK) complex mediates activation of transcription factor NF-κB by phosphorylation of IκB proteins. Its catalytic subunits, IKKα and IKKβ, require association with the regulatory IKKγ (NEMO) component to gain full basal and inducible kinase activity. However, the oligomeric compositio...

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Bibliografske podrobnosti
Main Authors: Tegethoff, Sebastian, Behlke, Joachim, Scheidereit, Claus
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2003
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC149477/
https://ncbi.nlm.nih.gov/pubmed/12612076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.6.2029-2041.2003
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