Effect of human leukocyte antigen heterozygosity on infectious disease outcome: The need for allele-specific measures

BACKGROUND: Doherty and Zinkernagel, who discovered that antigen presentation is restricted by the major histocompatibility complex (MHC, called HLA in humans), hypothesized that individuals heterozygous at particular MHC loci might be more resistant to particular infectious diseases than the corres...

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Detalhes bibliográficos

Publicado no:	BMC Med Genet
Principais autores:	Lipsitch, Marc, Bergstrom, Carl T, Antia, Rustom
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2003
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC149356/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12542841/ https://ncbi.nlm.nih.govhttps://doi.org/10.1186/1471-2350-4-2
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