Ergosterol Biosynthesis Inhibitors Become Fungicidal when Combined with Calcineurin Inhibitors against Candida albicans, Candida glabrata, and Candida krusei

Azoles target the ergosterol biosynthetic enzyme lanosterol 14α-demethylase and are a widely applied class of antifungal agents because of their broad therapeutic window, wide spectrum of activity, and low toxicity. Unfortunately, azoles are generally fungistatic and resistance to fluconazole is eme...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Onyewu, Chiatogu, Blankenship, Jill R., Del Poeta, Maurizio, Heitman, Joseph
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2003
Assuntos:	Mechanisms of Action: Physiological Effects
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC149324/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12604527/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.3.956-964.2003
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