Ergosterol Biosynthesis Inhibitors Become Fungicidal when Combined with Calcineurin Inhibitors against Candida albicans, Candida glabrata, and Candida krusei

Azoles target the ergosterol biosynthetic enzyme lanosterol 14α-demethylase and are a widely applied class of antifungal agents because of their broad therapeutic window, wide spectrum of activity, and low toxicity. Unfortunately, azoles are generally fungistatic and resistance to fluconazole is eme...

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Detalhes bibliográficos
Main Authors: Onyewu, Chiatogu, Blankenship, Jill R., Del Poeta, Maurizio, Heitman, Joseph
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC149324/
https://ncbi.nlm.nih.gov/pubmed/12604527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.3.956-964.2003
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