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Ergosterol Biosynthesis Inhibitors Become Fungicidal when Combined with Calcineurin Inhibitors against Candida albicans, Candida glabrata, and Candida krusei

Azoles target the ergosterol biosynthetic enzyme lanosterol 14α-demethylase and are a widely applied class of antifungal agents because of their broad therapeutic window, wide spectrum of activity, and low toxicity. Unfortunately, azoles are generally fungistatic and resistance to fluconazole is eme...

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Udgivet i:Antimicrob Agents Chemother
Principais autores: Onyewu, Chiatogu, Blankenship, Jill R., Del Poeta, Maurizio, Heitman, Joseph
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2003
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Mechanisms of Action: Physiological Effects
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC149324/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12604527/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.3.956-964.2003
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