In vivo tumor growth inhibition and biodistribution studies of locked nucleic acid (LNA) antisense oligonucleotides

Locked nucleic acids (LNA) are novel high-affinity DNA analogs that can be used as genotype-specific drugs. The LNA oligonucleotides (LNA PO ODNs) are very stable in vitro and in vivo without the need for a phosphorothiolated backbone. In this study we tested the biological fate and the efficacy in...

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Auteurs principaux: Fluiter, Kees, ten Asbroek, Anneloor L. M. A., de Wissel, Marit B., Jakobs, Marja E., Wissenbach, Margit, Olsson, Håkan, Olsen, Otto, Oerum, Henrik, Baas, Frank
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2003
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC149205/
https://ncbi.nlm.nih.gov/pubmed/12560491
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