In vivo tumor growth inhibition and biodistribution studies of locked nucleic acid (LNA) antisense oligonucleotides

Locked nucleic acids (LNA) are novel high-affinity DNA analogs that can be used as genotype-specific drugs. The LNA oligonucleotides (LNA PO ODNs) are very stable in vitro and in vivo without the need for a phosphorothiolated backbone. In this study we tested the biological fate and the efficacy in...

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izdano v:	Nucleic Acids Res
Principais autores:	Fluiter, Kees, ten Asbroek, Anneloor L. M. A., de Wissel, Marit B., Jakobs, Marja E., Wissenbach, Margit, Olsson, Håkan, Olsen, Otto, Oerum, Henrik, Baas, Frank
Format:	Artigo
Jezik:	Inglês
Izdano:	Oxford University Press 2003
Teme:	Articles
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC149205/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12560491/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkg185
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