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Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads

Inhibitory Smads, i.e. Smad6 and Smad7, are potent antagonists of the BMP–Smad pathway by interacting with activated bone morphogenetic protein (BMP) type I receptors and thereby preventing the activation of receptor-regulated Smads, or by competing with activated R-Smads for heteromeric complex for...

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Autors principals: Itoh, Fumiko, Asao, Hironobu, Sugamura, Kazuo, Heldin, Carl-Henrik, ten Dijke, Peter, Itoh, Susumu
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2001
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC149146/
https://ncbi.nlm.nih.gov/pubmed/11483516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.15.4132
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