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Site-Specific Mutagenesis Analysis of PBP 1A from a Penicillin-Cephalosporin-Resistant Pneumococcal Isolate

Our mutagenesis study has investigated all amino acid mutations in the penicillin-binding domain of PBP 1A from Hungarian pneumococcal isolate 3191 to determine the importance of every mutation in the development of penicillin and cefotaxime resistance. Our data reveal that mutations at amino acid p...

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Detalhes bibliográficos
Main Authors: Smith, Anthony M., Klugman, Keith P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC149026/
https://ncbi.nlm.nih.gov/pubmed/12499220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.1.387-389.2003
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