In Vitro and In Vivo Assessment of Linezolid Combined with Ertapenem: a Highly Synergistic Combination against Methicillin-Resistant Staphylococcus aureus

Linezolid in combination with ertapenem showed in vitro synergy against methicillin-resistant Staphylococcus aureus strains. We confirmed this interaction in vivo by using a rabbit endocarditis experimental model and simulation of the human pharmacokinetics in animals for both antibiotics. Linezolid...

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Autori principali: Jacqueline, Cedric, Caillon, Jocelyne, Grossi, Olivier, Le Mabecque, Virginie, Miegeville, Anne-Françoise, Bugnon, Denis, Batard, Eric, Potel, Gilles
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2006
Soggetti:
Experimental Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1489782/
https://ncbi.nlm.nih.gov/pubmed/16801442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01501-05
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