In Vivo Activity of a Novel Anti-Methicillin-Resistant Staphylococcus aureus Cephalosporin, Ceftaroline, against Vancomycin-Susceptible and -Resistant Enterococcus faecalis Strains in a Rabbit Endocarditis Model: a Comparative Study with Linezolid and Vancomycin

We assessed the in vitro and in vivo efficacy of the novel parenteral broad-spectrum cephalosporin ceftaroline against Enterococcus faecalis in time-kill experiments and in a rabbit endocarditis model with simulated human dosing. Ceftaroline was more active than either vancomycin or linezolid agains...

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Detalhes bibliográficos
Main Authors: Jacqueline, Cédric, Caillon, Jocelyne, Le Mabecque, Virginie, Miègeville, Anne-Françoise, Ge, Yigong, Biek, Donald, Batard, Eric, Potel, Gilles
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2786336/
https://ncbi.nlm.nih.gov/pubmed/19752276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00984-09
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