Cyclin D1 Regulates Cellular Migration through the Inhibition of Thrombospondin 1 and ROCK Signaling

Cyclin D1 is overexpressed in human tumors, correlating with cellular metastasis, and is induced by activating Rho GTPases. Herein, cyclin D1-deficient mouse embryo fibroblasts (MEFs) exhibited increased adhesion and decreased motility compared with wild-type MEFs. Retroviral transduction of cyclin...

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Main Authors: Li, Zhiping, Wang, Chenguang, Jiao, Xuanmao, Lu, Yinan, Fu, Maofu, Quong, Andrew A., Dye, Chip, Yang, Jianguo, Dai, Maozheng, Ju, Xiaoming, Zhang, Xueping, Li, Anping, Burbelo, Peter, Stanley, E. Richard, Pestell, Richard G.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1489104/
https://ncbi.nlm.nih.gov/pubmed/16705174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.02124-05
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