Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function

Cyclin D1 promotes nuclear DNA synthesis through phosphorylation and inactivation of the pRb tumor suppressor. Herein, cyclin D1 deficiency increased mitochondrial size and activity that was rescued by cyclin D1 in a Cdk-dependent manner. Nuclear respiratory factor 1 (NRF-1), which induces nuclear-e...

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Detalhes bibliográficos
Main Authors: Wang, Chenguang, Li, Zhiping, Lu, Yinan, Du, Runlei, Katiyar, Sanjay, Yang, Jianguo, Fu, Maofu, Leader, Jennifer E., Quong, Andrew, Novikoff, Phyllis M., Pestell, Richard G.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1518800/
https://ncbi.nlm.nih.gov/pubmed/16864783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603363103
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