Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function

Cyclin D1 promotes nuclear DNA synthesis through phosphorylation and inactivation of the pRb tumor suppressor. Herein, cyclin D1 deficiency increased mitochondrial size and activity that was rescued by cyclin D1 in a Cdk-dependent manner. Nuclear respiratory factor 1 (NRF-1), which induces nuclear-e...

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Bibliografski detalji
Glavni autori: Wang, Chenguang, Li, Zhiping, Lu, Yinan, Du, Runlei, Katiyar, Sanjay, Yang, Jianguo, Fu, Maofu, Leader, Jennifer E., Quong, Andrew, Novikoff, Phyllis M., Pestell, Richard G.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2006
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1518800/
https://ncbi.nlm.nih.gov/pubmed/16864783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603363103
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