The Role of IFN-γ and TNF-α-Responsive Regulatory Elements in the Synergistic Induction of Indoleamine Dioxygenase

Indoleamine 2,3-dioxygenase (IDO), which enzymatically depletes tryptophan, is an important antimicrobial defense mechanism against susceptible pathogens. In human epithelial cells, interferon-γ (IFN-γ)-induced IDO expression is transcriptionally enhanced by tumor necrosis factor-α (TNF-α). The purp...

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Hlavní autoři: ROBINSON, CORY M., HALE, PHILLIP T., CARLIN, JOSEPH M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2005
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1488823/
https://ncbi.nlm.nih.gov/pubmed/15684619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/jir.2005.25.20
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