Cell-by-cell scanning of whole mitochondrial genomes in aged human heart reveals a significant fraction of myocytes with clonally expanded deletions.

Quantitative information on the cell-to-cell distribution of all possible mitochondrial DNA (mtDNA) mutations in young and aged tissues is needed to assess the relevance of these mutations to the aging process. In the present study, we used PCR amplification of full-length mitochondrial genomes from...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Khrapko, K, Bodyak, N, Thilly, W G, van Orsouw, N J, Zhang, X, Coller, H A, Perls, T T, Upton, M, Vijg, J, Wei, J Y
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 1999
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148812/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10325435/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/27.11.2434
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