Cell-by-cell scanning of whole mitochondrial genomes in aged human heart reveals a significant fraction of myocytes with clonally expanded deletions.

Quantitative information on the cell-to-cell distribution of all possible mitochondrial DNA (mtDNA) mutations in young and aged tissues is needed to assess the relevance of these mutations to the aging process. In the present study, we used PCR amplification of full-length mitochondrial genomes from...

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Опубліковано в::	Nucleic Acids Res
Автори:	Khrapko, K, Bodyak, N, Thilly, W G, van Orsouw, N J, Zhang, X, Coller, H A, Perls, T T, Upton, M, Vijg, J, Wei, J Y
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Oxford University Press 1999
Предмети:	Research Article
Онлайн доступ:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148812/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10325435/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/27.11.2434
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