Cell-by-cell scanning of whole mitochondrial genomes in aged human heart reveals a significant fraction of myocytes with clonally expanded deletions.

Quantitative information on the cell-to-cell distribution of all possible mitochondrial DNA (mtDNA) mutations in young and aged tissues is needed to assess the relevance of these mutations to the aging process. In the present study, we used PCR amplification of full-length mitochondrial genomes from...

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書誌詳細

出版年:	Nucleic Acids Res
主要な著者:	Khrapko, K, Bodyak, N, Thilly, W G, van Orsouw, N J, Zhang, X, Coller, H A, Perls, T T, Upton, M, Vijg, J, Wei, J Y
フォーマット:	Artigo
言語:	Inglês
出版事項:	Oxford University Press 1999
主題:	Research Article
オンライン･アクセス:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148812/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10325435/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/27.11.2434
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