Cell-by-cell scanning of whole mitochondrial genomes in aged human heart reveals a significant fraction of myocytes with clonally expanded deletions.

Quantitative information on the cell-to-cell distribution of all possible mitochondrial DNA (mtDNA) mutations in young and aged tissues is needed to assess the relevance of these mutations to the aging process. In the present study, we used PCR amplification of full-length mitochondrial genomes from...

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Bibliografische gegevens

Gepubliceerd in:	Nucleic Acids Res
Hoofdauteurs:	Khrapko, K, Bodyak, N, Thilly, W G, van Orsouw, N J, Zhang, X, Coller, H A, Perls, T T, Upton, M, Vijg, J, Wei, J Y
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Oxford University Press 1999
Onderwerpen:	Research Article
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148812/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10325435/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/27.11.2434
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