Lipophilic pro-oligonucleotides are rapidly and efficiently internalized in HeLa cells.

Model t-Bu-SATE pro-dodecathymidines labeled with fluorescein and exhibiting various lipophilicities were evaluated for their uptake by cells in culture. Pro-oligonucleotides with appropriate lipophilicity were found to permeate across the HeLa cell membrane much more extensively than the control ph...

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Publié dans:	Nucleic Acids Res
Auteurs principaux:	Vivès, E, Dell'Aquila, C, Bologna, J C, Morvan, F, Rayner, B, Imbach, J L
Format:	Artigo
Langue:	Inglês
Publié:	Oxford University Press 1999
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148675/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10497272/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/27.20.4071
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