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Lipophilic pro-oligonucleotides are rapidly and efficiently internalized in HeLa cells.

Model t-Bu-SATE pro-dodecathymidines labeled with fluorescein and exhibiting various lipophilicities were evaluated for their uptake by cells in culture. Pro-oligonucleotides with appropriate lipophilicity were found to permeate across the HeLa cell membrane much more extensively than the control ph...

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Udgivet i:Nucleic Acids Res
Principais autores: Vivès, E, Dell'Aquila, C, Bologna, J C, Morvan, F, Rayner, B, Imbach, J L
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 1999
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148675/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10497272/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/27.20.4071
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